I don't read comics much anymore. Every once in a while, I'll read through the paper and take some time to go through the comics. I'm never really impressed. For the record, my least favorite comic in the whole world is Ziggy.
However, there is a comic out there that is pure brilliance. The name of the comic is Basic Instructions and it's written by Scott Meyer. He uses situational comedy and the comics are hilarious. I haven't read through them all, but the ones I've read are awesome. The more you read, the more you'll like it. He often uses the same characters (boss, wife, friend, etc). If you have the time, I suggest going to Basic Instructions and reading through some of the archives. It's an awesome comic that deserves some recognition and you won't be disappointed. If you're too lazy for that, here are a few good ones (click to enlarge):